Here is a brief overview of how to add block programs from ever running, even if those have been previously installed.
Here is a brief overview of how to add Trusted Users. These users will be able to fine-tune protection settings.
Here is a brief overview of how to add new software publishers, so your application control can be done not only based on file hashes, but also on which publisher created a specific application. This way you can make sure that all programs signed by Microsoft or Adobe run great.
Here is a brief overview of how to add specific new programs and and allow them to run.
Here is a brief overview of how to use Maintenance Mode to make sure changes to programs during patching or update sessions are reflected in your control list and the newly update programs can run freely.